Uncertainty Evaluation in Carbamazepine Determination in Human Plasma by HPLC-MS/MS / 中国药师
China Pharmacist
;
(12): 419-423, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-487721
ABSTRACT
Objective:
To evaluate the uncertainty in carbamazepine ( CBZ) determination in human plasma by HPLC-MS/MS.Methods:
The whole process of CBZ determination was analyzed and the uncertainty sources were established, and then the uncertainty was evaluated and combined, and the expanded uncertainty was also calculated.Results:
The expanded uncertainty of CBZ with low (7.46 ng·ml-1) and high (745 ng·ml-1) levels was 0.410 ng·ml-1 and 33.400 ng·ml-1, respectively (P=95%, k=2).Conclusion:
The uncertainty in CBZ determination in human plasma by HPLC-MS/MS is mainly caused by recovery, sample prepara-tion and matrix effect for low concentration, and by sample preparation and repeatability for high concentration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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