Verification of the interaction between ASGPR and HBV preS1 protein / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
; (6): 292-297, 2016.
Article
in Zh
| WPRIM
| ID: wpr-487881
Responsible library:
WPRO
ABSTRACT
Objective To verify the interaction between asialoglycoprotein receptor (ASGPR)and hepatitis B virus (HBV)preS1 protein in vivo and in vitro ,and identify ASGPR as a cell-surface receptor for HBV,which could elucidate the molecular mechanism of HBV infection.Methods The preS1-ASGPR interaction was examined in mammalian two-hybrid and coimmunoprecipitation system by strictly following the manufacturer’s instructions.Results ASGPR interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro .Conclusion ASGPR may be a candidate receptor for HBV that mediates further step of HBV entry.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Journal of xi'an jiaotong university(medical sciences)
Year:
2016
Type:
Article