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Verification of the interaction between ASGPR and HBV preS1 protein / 西安交通大学学报(医学版)
Article in Zh | WPRIM | ID: wpr-487881
Responsible library: WPRO
ABSTRACT
Objective To verify the interaction between asialoglycoprotein receptor (ASGPR)and hepatitis B virus (HBV)preS1 protein in vivo and in vitro ,and identify ASGPR as a cell-surface receptor for HBV,which could elucidate the molecular mechanism of HBV infection.Methods The preS1-ASGPR interaction was examined in mammalian two-hybrid and coimmunoprecipitation system by strictly following the manufacturer’s instructions.Results ASGPR interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro .Conclusion ASGPR may be a candidate receptor for HBV that mediates further step of HBV entry.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of xi'an jiaotong university(medical sciences) Year: 2016 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of xi'an jiaotong university(medical sciences) Year: 2016 Type: Article