A Case of Recalcitrant Psoriasis Improved with Tacrolimus (FK 506) / 대한피부과학회지

ABSTRACT

Tacrolimus(FK 506) is a powerful immunosuppressant. Recently, topical and systemic tacrolimus was known to have therapeutic effects in various dermatologic diseases such as atopic dermatitis, psoriasis, pyodema gangrenosum, and Beh et's disease. A 48-year-old woman presented with psoriasis of 40 years duration, which was recalcitrant to any therapies including topical steroids and calcipotriol, UVB, PUVA, acitretin, cyclosporine, and methotrexate. Therefore, systemic tacrolimus treatment, at a dose of 2 to 6 mg per day, was initiated, and complete resolution of the lesions was observed after 2 months. We report a case of recalcitrant psoriasis improved with tacrolimus.