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Expression of doublecortin-like kinase 1 in colorectal cancers and colorectal adenomas and its clinical significance / 中国医师杂志
Journal of Chinese Physician ; (12): 406-409, 2016.
Article in Chinese | WPRIM | ID: wpr-488433
Responsible library: WPRO
ABSTRACT
Objective To investigate the expression of doublecortin-like kinase 1 (DCLK1) in colorectal cancer and colorectal adenomas,and it's role in the development and progression of colorectal carcinoma,and explore the relationship of the DCLK1 expression and prognosis in colorectal cancer patients with diabetes medical history.Methods Expression of DCLK1 in 70 cases of colorectal cancers,70 cases of para-carcinoma tissues,and 35 cases of tubulovillous adenomas were detected by immunohistochemical method.Results (1) The DCLK1 high expression rate in colorectal cancers was 41.4% (29/70),and 45.7% (16/35) in tubular villous adenomas,both significantly higher than the para-carcinoma tissues (4.3%;3/70) (P <0.01).(2) DCLK1 high positive expression had statistical significance with pathological grading (P < 0.01),infiltration depth (P < 0.05),lymph node metastasis (P< 0.05),vascular invasion (P <0.05),and distant metastasis (P <0.01).(3) There was no obvious correlation between the Diabetes medical history,expression of DCLK1,and prognosis of patients.Conclusions DCLK1 has high positive expression in colorectal carcinomas,and may have certain significance for the early clinical diagnosis and prognostic judgment of colorectal cancers.The expression of DCLK1 and prognosis of colorectal cancers has no obvious correlation with diabetes medical history.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Chinese Physician Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Chinese Physician Year: 2016 Type: Article