Hepatitis C virus infection increases the incidence of intrahepatic cholangiocarcinoma: a Meta-analysis / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
;
(12): 33-36, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-488626
ABSTRACT
Objective A meta-analysis was conducted to evaluate the correlation between hepatitis C virus (HCV) infection and the incidence of intrahepatic cholangiocarcinoma (ICC).Methods EMBASE,MEDLINE,Web of Science,CNKI,Weipu and Wanfang databases were retrieved to identify eligible studies which were published between January 2000 and May 2015.Pooled odds ratios (OR) with 95% confidence interval (95% CI) were calculated using RevMAN 5.3.Results 14 case-control studies and 2 cohort studies were included in this study.As there was great heterogeneity among these 16 studies (Chi2 =53.18,df =15,I2 =72%,P <0.05),the random-effect model was employed.The combined risk estimates of all the studies showed a significant increase in ICC incidence with HCV infection (OR =3.96,95% CI 2.63-5.95,P < 0.05).The Begg funnel plot showed no evidence of publication bias.Conclusion HCV infection is related to an increased risk of ICC incidence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Incidence study
/
Observational study
/
Risk factors
/
Systematic reviews
Language:
Chinese
Journal:
Chinese Journal of Hepatobiliary Surgery
Year:
2016
Type:
Article
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