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Correlation between serum cystatin-C levels and cognitive impairment / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 352-354, 2016.
Article in Chinese | WPRIM | ID: wpr-489306
ABSTRACT
Objective To investigate the correlation between serum cystatin-C (Cys-C) levels and cognitive impairment.Methods A perspective study involving 273 patients in our hospital was performed from 2013 to 2015.They were divided into the cognitive impairment group and the control group.Cys-C measurement results and cognitive impairment assessment scores were collected.Possible influence factors were adjusted,and the correlation between Cys-C levels and mild cognitive impairment was analyzed.Results The distribution of age,hypertension,diabetes mellitus,smoking,drinking,dyslipidemia,and creatinine showed significant differences between the groups at different Cys-C levels (all P<0.05).There was a significant difference in the Cys-C level between the cognitive impairment group and the control group [(0.727±0.082) mg/L vs.(0.514±0.045)mg/L,t=23.68,P<0.01].The Cys-C level was negatively correlated with the scores of mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) in the cognitive impairment group (r =-0.318 and -0.572,P<0.05).The incidence of cognitive impairment was elevated with increasing Cys-C levels (x2 =13.12,P<0.01).Logistic regression analysis showed that high levels of Cys-C (OR=3.298,95% CI1.417-7.675,P=0.001),history of diabetes mellitus (OR=7.971,95% CI3.036-31.562,P =0.03),education level (OR =2.237,95 % CI1.022-4.896,),smoking (OR =5.692,95 % CI1.060-2.614),drinking (OR=1.227,95% CI0.083-1.228),and dyslipidemia (OR=2.267,95% CI1.177-4.366) are independent risk factors for cognitive impairment.Conclusions High serum cystatin C levels are closely correlated with the risk of cognitive impairment occurrence.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2016 Type: Article