Roles of MTH1 gene in the occurrence and treatment of cancers / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 26-28, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-489655
ABSTRACT
MTH1 protein can mitigate DNA damage which caused by reactive oxygen species through hydrolyzing oxidized deoxy-ribonucleoside triphosphate.MTH1 is highly expressed in various cancers, so as to maintain the viability of cancer cells.MTH1 is closely related to tumor associated genes such as microRNA,RAS gene and p53 gene.Moreover, MTH1 inhibitors can selectively suppress the proliferation of cancers,which is a potential new target in tumor therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2016
Type:
Article
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