Research progress of metabolic syndrome in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
;
(24): 631-634, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-489764
ABSTRACT
Congenital adrenal hyperplasia (CAH) owing to steroid 21-hydroxylase deficiency (21-OHD) was a relatively frequent of autosomal recessive disorders characterized by the inactivation of the steroid-synthesizing enzyme in the adrenocortex.Corticosteroids (glucocorticoids and mineralocorticoid) replacement therapy was the primary treatment of 21-OHD.The main objective of 21-OHD treatment in children was to maintain normal growth.Inadequate or excessive treatment was commonly observed.A number of studies reported that 21-OHD adult were at increasing risk of developing metabolic syndrome and cardiovascular events.However,there was few researches on 21-OHD children with metabolic disorders,and no domestic reports.The article summarized recent clinical research progresses in research on the alterations of lipid and carbohydrate metabolism in children with classic 21-OHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Applied Clinical Pediatrics
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS