Stabilizing Microtubular Network Facilitates the Intracellular Growth of Orientia tsutsugamushi
Journal of Bacteriology and Virology
;
: 51-57, 2006.
Article
in English
| WPRIM
| ID: wpr-49011
ABSTRACT
Microtubule network provides many intracellular microbes with an efficient way to move within host cells. Orientia tsutsugamushi move from the cell periphery to the microtubule organizing center (MTOC) by dynein-dependent mechanism. In this study, we investigated the role of microtubule on the growth of O. tsutsugamushi. The treatment of infected cells with taxol as well as daunomycin enhanced the bacterial growth in contrast to colchicine. Immunofluorescent (IF) staining of taxol-treated cells exhibited that O. tsutsugamushi clustered tightly near the nucleus with thick bundles of microtubules, whereas dispersed in the cytoplasm in colchicine-treated cells. These results suggest that microtubule network facilitate the growth of O. tsutsugamushi.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orientia tsutsugamushi
/
Daunorubicin
/
Colchicine
/
Paclitaxel
/
Microtubule-Organizing Center
/
Cytoplasm
/
Microtubules
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2006
Type:
Article
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