Formula Optimization of Ropivacaine Hydrochloride Transdermal Gel / 中国药师
China Pharmacist
;
(12): 660-664, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-490898
ABSTRACT
Objective:
To optimize the formula of ropivacaine hydrochloride transdermal gel.Methods:
The steady transdermal rate and cumulative transdermal percentage in 24 h of ropivacaine hydrochloride gel were used as the indices, an orthogonal design was applied to select the optimal formula, and Design Expert 8. 0. 5. 0 software was used to analyze the results.Results:
The optimal formula con-tained 2% carbomer, 10% propylene-glycol and 5% Azone. The steady transdermal rate of the optimal formula was 0. 6951 mg·h-1 · cm-2 . The cumulative transdermal percentage in 24 h of the optimal formula was 91. 04%, which was 22. 79% higher than that of ropiva-caine hydrochloride solution with the same concentration. Design Expert 8. 0. 5. 0 software could predict the steady transdermal rate and cumulative transdermal percentage in 24 h of the optimal formula.Conclusion:
The preparation design is reasonable, and the gel has promising properties, which is suitable for skin local application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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