Stem cell conversion technology is a footstone for stem cell basic and clinical research in the future / 中国组织工程研究

ABSTRACT

BACKGROUND:Stem cel conversion technology has become an active area in the field of stem cel research, and it also has a tremendous boost on both the stem cel basic research and clinical study. OBJECTIVE:To review the research status and the current progress of stem cel conversion technology. METHODS:In the titles and summaries, the “stem cels, conversion, differentiation” in Chinese and English served as the search terms to search articles related to stem cels technology published from January 2000 to April 2015 in CNKI and PubMed databases. The latest articles or articles published on the authoritative journals were preferred. Totaly 121 articles were obtained after initial survey, and according to the inclusion criteria, 64 articles were selected for overview. RESULTS AND CONCLUSION:The progress of stem cels conversion technology has driven the development of the entire stem cel research, including modifying the ratio of culture medium, increasing specific inducers, proteins, enzymes or receptors, injecting specific genes, using new oxidizing agents, modifying culture microenvironment, culture under hypoxia, scaffold usage, applying transgenic technology, three-dimensional spherical culture or co-culture. Stem cel conversion technology wil definitely increase the conversion rate of stem cels, which can bring hope for the treatment of refractory diseases. Cite this article:Tu XS. Stem cel conversion technology is a footstone for stem cel basic and clinical research in the future. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(1):128-134.