Clinical study on Huayu-Zhentong capsule combined with traditional manipulation for after operation of lumbar intervertebral disc herniation / 国际中医中药杂志

ABSTRACT

Objective To evaluate the efficacy of Huayu-Zhentong capsule combined with traditional manipulation in patients with inflammatory cytokines after operation of lumbar intervertebral disc herniation.Methods A total of 80 patients with orthopedic inpatients were enrolled and divided into two group by random number table method:a treatment group (40 patients) and a control group (40 patients).On this basis,the control group was added to loxoprofen sodium dispersible tablets,the treatment group was added to Huayu-Zhentong capsule.2 groups were continuous treated for 2 courses.Flow cytometry was used to detect the level of IL-8 and IL-6 before and after treatment,and the patients were evaluated by VAS.The clinical efficacy was evaluated by Oswestry ODI.Results After treatment,the VAS score (2.22 ± 0.31 vs.3.54 ± 0.67,t=11.309) and ODI (10.51 ± 3.22 vs.15.54 ± 6.21,t=4.548) of the treatment group were decreased than the control group (both P＜0.01).Lymphocyte IL-6(0.58％ ± 0.20％ vs.0.84％ ± 0.32％,t=4.358),IL-8(0.41％ ± 0.11％ vs.0.61％ ± 0.20％,t=5.542),mononuclear cells IL-6(25.31％ ± 4.26％ vs.29.19％ ± 5.32％,t=3.604),IL-8(17.80％ ± 2.81％ vs.3.31％ ± 3.77％,t=7.411) of the treatment group were lower than the control group (all P＜0.01).The total effective rate (100％ vs.75.0％) of the treatment group was better than the control group (x2=9.257,P=0.002).Conclusions Huayu-Zhentong capsule combinated with traditional manipulation can reduce inflammatory cytokines IL-6 and IL-8 levels in patients with LIDH.Its curative effect is better than traditional manipulation with loxoprofen sodium dispersible tablets.