Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 229-233, 2013.
Article
in English
| WPRIM
| ID: wpr-49138
ABSTRACT
BACKGROUND:
Shivering is a frequent event during spinal anesthesia and meperidine is a well-known effective drug for prevention and treatment of shivering. Nefopam is a non-opiate analgesic and also known to have an anti-shivering effect. We compared nefopam with meperidine for efficacy of prevention of shivering during spinal anesthesia.METHODS:
Sixty five patients, American Society of Anesthesiologists physical status I or II, aged 20-65 years, scheduled for elective orthopedic surgery under spinal anesthesia were investigated. Patients were randomly divided into two groups, meperidine (Group M, n = 33) and nefopam (Group N, n = 32) groups. Group M and N received meperidine 0.4 mg/kg or nefopam 0.15 mg/kg, respectively, in 100 ml of isotonic saline intravenously. All drugs were infused for 15 minutes by a blinded investigator before spinal anesthesia. Blood pressures, heart rates, body temperatures and side effects were checked before and at 15, 30, and 60 minutes after spinal anesthesia.RESULTS:
The incidences and scores of shivering were similar between the two groups. The mean arterial pressures in Group N were maintained higher than in Group M at 15, 30, and 60 minutes after spinal anesthesia. The injection pain was checked in Group N only and its incidence was 15.6%.CONCLUSIONS:
We conclude that nefopam can be a good substitute for meperidine for prevention of shivering during spinal anesthesia with more stable hemodynamics, if injection pain is effectively controlled.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthopedics
/
Research Personnel
/
Shivering
/
Body Temperature
/
Incidence
/
Arterial Pressure
/
Heart Rate
/
Hemodynamics
/
Anesthesia, Spinal
/
Meperidine
Type of study:
Incidence study
/
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2013
Type:
Article
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