Logistic regression analysis on risk factors of autism spectrum disorders / 中华实用儿科临床杂志

ABSTRACT

Objective To explore the possible risk factors for autism spectrum disorders (ASD),and to pro-vide a basis for exploring the etiology of the disease.Methods This case -control study included 68 patients diag-nosed as ASD for a first lifetime(according to the fourth edition of the American Diagnostic and Statistical Manual of Mental Disordersfor ASD diagnosis)from May 201 4 to January 201 5,and 77 non -ASD controls (normal children, matched on gender)in Jiangxi Children′s Hospital were selected to undergo the risk factor survey for ASD.The survey content included 1 0 categoriesgeneral status,birth,feeding,the past history,mother′s pregnancy and her health condi-tion during pregnancy and environmental exposure,parents′occupational exposure,family history and relevant test re-sults.Logistic regression analysis was performed to analyze the results of the survey.Results The possible risk factors for ASD increased if mother had virus infection 2 years before pregnant (OR =7.97,95%CI2.42 -26.31 ),had occu-pational exposure (OR =3.99,95%CI1 .27 -1 2.52),volatile organic compounds exposure during pregnancy (OR =22.21 ,95%CI2.28 -21 6.09),as well as living closely to transport passage ways during pregnancy (OR =0.59,95%CI0.38 -0.93)or having a family heredity history (OR =58.50,95%CI5.81 -589.57).Breastfeeding (OR =0.81 ,95%CI0.66 -0.98)might be a protective factor in ASD.Conclusions In addition to genetic factors,the ute-rine environment from conception to birth and growth environment play an important role in the pathogenesis of ASD.