Expression pattern of MiR-146a and its correlation with antibody titers in human brucellosis / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 230-233, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-491874
ABSTRACT
Objective:
To investigate the expression pattern of microRNA-146a in Brucella patients and its correlation with antibody titers.Methods:
By using real time PCR assay, expression levels of microRNA-146a in sera samples from 20 brucellosis patients and 20 healthy volunteers were analyzed.The correlation between expression level of microRNA-146a and serum antibody titers were analyzed with SPSS17.0.Results:
A quantification curve of microRNA-146a was constructed with synthesized standard.Expression levels of microRNA-146a among brucellosis patients were significantly lower than those in 20 healthy volunteers (P<0.001).For brucellosis patients,the expression level of microRNA-146a was negatively related with antibody titers (P<0.05).Conclusion:
Expression of miRNA-146a in brucellosis patients was significantly inhibited and negatively related with antibody titer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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