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Determination of Aniline,2-Aminophenol and 4-Aminophenol in Mesalazine Sustained Release Granules by Gas Chromatography / 医药导报
Herald of Medicine ; (12): 185-188, 2016.
Article in Chinese | WPRIM | ID: wpr-491885
ABSTRACT
Objective To establish a gas chromatography ( GC) method for determination of aniline,2-aminophenol and 4-aminophenol in mesalamine sustained release granules. Methods An HP-5 (10 m×0.53 mm,2.65 μm) capillary GC column was adopted. The carrier gas was high purity nitrogen at a flow rate of 15 mL.min-1 . The inlet temperature was controlled at 280 ℃ and the FID detector temperature was 300℃. The oven temperature was initially held at 70℃ for 2 min and was then programmed to 150 ℃ at 10℃.min-1 and held for 6 min. Results A good resolution was obtained between the peaks of the 3 impurities at chromatographic conditions above. The recoveries of aniline, 2-aminophenol and 4-aminophenol were among 98.04% to 103.00%. The precision and linearity equations were good. Conclusion The method can be adopted for the quality control of mesalazine sustained release granules.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Herald of Medicine Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Herald of Medicine Year: 2016 Type: Article