Advances in strategies to overcome the blood-brain barrier / 国际药学研究杂志

ABSTRACT

A major reason for the failure of research and development for central nevous system(CNS)agents and acetylcholin?esterase reactivators is their inability to cross blood-brain barrier(BBB)to reach the brain. Mostly available agents have limited perme?ability via BBB to effectively treat CNS disorders. Hence,the major challenge in agents development and delivery for the neurological diseases is to overcome the main impediment for the brain agents delivery. In this review,we summarize each of these approaches, highlight their successes and obstacles,discuss transporters of potential targets for brain agents delivery,and provide an insight into some of recent advances made in brain agents delivery,in order to improve the potential utility of these compounds in therapeutics. The present review suggests that based on the structure and function of BBB,future work continue to focus more closely on molecular mechanisms that affect brain permeation,transporters and intracellular signaling pathways. Ultimately,the achievement of these stud?ies is to find safe and effective delivery strategies for administering agents to the brain and playing a therapeutic role.