Therapeutic effect of captopril on aged patients with essential hypertension and complications / 心血管康复医学杂志

ABSTRACT

Objective:To observe therapeutic effect of captopril treatment on aged patients with essential hyperten‐sion (EH) and complications and evaluate its safety .Methods:A total of 116 aged EH patients ,who were compli‐cated with dyslipidemia ,diabetes mellitus etc . were selected from our hospital .According to random number table , they were randomly and equally divided into atenolol control group and captopril group (received captopril based on treatment of atenolol control group) .Blood pressure ,heart rate ,fasting plasma glucose (FPG) and blood lipids were observed and compared between two groups ,the therapeutic effect and adverse reactions were assessed .Re‐sultsAfter treatment ,total effective rate of captopril group was significantly higher than that of atenolol control group (98.28% vs .87.93% ,P<0.05);compared with atenolol control group ,there were significant reductions in levels of blood pressure [ (131.20 ± 11.02/82.01 ± 6.75) mmHg vs .(115.62 ± 10.27/75.68 ± 5.21) mmHg] ,heart rate [ (65.14 ± 6.32) beats/min vs .(57.21 ± 4.02) beats/min] ,FPG [ (4.75 ± 1.36) mmol vs .(3.65 ± 1.24) mmol] ,total cholesterol [ (2.69 ± 0.58) mmol/L vs .(2.10 ± 0.41) mmol/L] ,triglyceride [ (0.96 ± 0.41) mmol/L vs .(0.72 ± 0.35) mmol/L] and low density lipoprotein cholesterol [ (1.95 ± 0.57) mmol/L vs .(1.71 ± 0.40) mmol/L] in captopril group ,P<0.05 or <0.01 .There were no obvious adverse reactions occurred in both groups . Conclusion:Compared with atenolol ,captopril treatment possesses better therapeutic effect without adverse reac‐tions in aged patients with essential hypertension and complications ,which is worth extending .