Relationship between collagenⅠgene COL1A2 polymorphisms and atherosclerotic cerebral infarction, stability of carotid arteriosclerotic plaque / 临床神经病学杂志

ABSTRACT

Objective To observe the relationship between rs42524 polymorphisms of collagen Ⅰ COL1A2 gene and atherosclerotic cerebral infarction, stability of carotid arteriosclerotic plaque.Methods Carotid ultrasound detection by Color Doppler ultrasonography was used to detect 289 patients with acute atherosclerotic cerebral infarction.These patients were divided into stable plaque and vulnerable plaque subgroups according to the carotid atherosclerotic plaque stability.Then 107 healthy individuals who had no carotid plaque were collected as the control group.Rs42524 polymorphism of COL1A2 gene was detected by PCR-restriction fragment length polymorphism.The results were analyzed.Results There were no significant differences of the frequencies of genotypes and alleles of rs42524 of COL1A2 gene between the cerebral infarction group and the control group (all P>0.05).According to the results of carotid ultrasound detection, the cerebral infarction group patients were divided into stable plaque subgroup including 108 cases, and vulnerable plaque subgroup including 181 cases.Rs42524 of COL1A2 gene showed no significant differences in the frequencies of alleles and genotypes between stable plaque subgroup and vulnerable plaque subgroup ( all P>0.05) .Conclusion Rs42524 polymorphism of COL1A2 gene is meaningless to the onset risk of atherosclerotic cerebral infarction and the stability of carotid atherosclerotic plaque.