The reference value of NGAL in sepsis patients with AKI to choose the timing of CRRT treatment / 中国基层医药

ABSTRACT

Objective To evaluate the reference value of NGAL in sepsis patients with AKI to choose the timing of continuous renal replacement therapy (CRRT)treatment.Methods 62 sepsis patients with AKI were enrolled in this study.Within 24 hours after the diagnosis,the patients'urine samples were collected,the urinary NGAL levels were measured by ELISA.At the same time,the clinical parameters were collected,such as serum creatinine, blood urea nitrogen,blood leukocytes,etc.Depending on whether patients need to receive CRRT,the patients were divided into sepsis CRRT group and septic non CRRT group,the clinical data of the two groups were compared.ROC analysis was performed to evaluate the reference value of NGAL in sepsis patients with AKI to choose the timing of CRRT treatment.Results Total 62 sepsis patients with AKI were enrolled in this study.Ultimately,27 patients received CRRT treatment.Within 24 hours after the diagnosis,the clinical parameters of the two groups,such as serum creatinine,blood urea nitrogen and blood leukocytes showed no significant differences (all P >0.05);but the urinary NGAL level of sepsis CRRT group[(7.9 ±2.5)pg·mL -1 ·cr -1 ]was significantly higher than sepsis non CRRT group[(4.1 ±1.3)pg·mL -1 ·cr -1 ](t =12.912,P <0.01).ROC analysis showed that the area under the curve (AUC)for the value of NGAL in sepsis patients with AKI to choose the timing of CRRT treatment was 0.892(95%CI0.775 ~0.898,P <0.01).Conclusion Urinary NGAL has a certain reference value in sepsis patients with AKI to choose the timing of CRRT treatment,could contribute to early intervention CRRT treatment.