Study on glycemic control of the gestational diabetes mellitus to the neonatal immunity / 中国基层医药

ABSTRACT

Objective To investigate the influence of the glycemic control level of gestational diabetes melli-tus (GDM)to neonatal immunity system function.Methods 41 newborns whose mothers suffered from GDM and treated,were selected as the observation group.Inside the observation group,based on the glycemic control level,they were divided into 25 cases in higher satisfaction group and 16 cases in lower satisfaction group.20 cases from normal full -term and single -birth pregnancy were selected as the control group.The levels of serum immunoglobulin and the complement were observed in three different groups.Results The level of serum immunoglobulin(IgG)in lower satisfaction group was (5.2 ±1.4)g/L,which was significantly lower than higher satisfaction group (10.4 ±2.2)g/L and control group (10.3 ±1.9)g/L(t =8.957,8.470,P <0.01).The C3 and C4 levels in the higher satisfaction group [C3 (59.3 ±12.9)g/L,C4(39.4 ±11.2)g/L]and control group[C3 (59.9 ±13.8)g/L,C4 (39.8 ± 10.6)g/L]were significantly higher than the lower satisfaction group [C3(40.6 ±10.5)g/L,C4 (21.9 ±6.3)g/L] (t =4.612,4.854,5.956,5.685,all P <0.01 ).Conclusion Higher level of glycemic control on GDM mothers benefits neonatal serum immunoglobulin and the complement,and has positive impact on the immunity system and liver function.