Analysis of Plasma Levels of Omentum-1 and Vaspin in Patients With Acute Coronary Syndrome / 中国循环杂志

ABSTRACT

Objective: To observe the changes of plasma levels of omentin-1 and vaspin in patients with acute coronary syndrome (ACS). Methods: Our research included in 2 groups ACS group, the patients with conifrmed diagnosis in our hospital from 2013-05 to 2013-09,n=100 including 52 male, 48 female and Control group, the patients with simultaneous coronary angiography excluded CAD,n=88. Plasma levels of omentin-1 and vaspin were examined by ELISA and the differences were compared between 2 groups. Results: Plasma levels of omentin-1 and vaspin in ACS group were lower than Control group (t=2.718,P<0.05) and (t=2.416,P<0.05). Correlation analysis presented that in ACS group, omentin-1 level was negatively related to total cholesterol (TC) (r=-0.702,P<0.05) and C-reactive protein (CRP) (r=-0.714,P<0.05); vaspin was negatively related to TC (r=-0.655, P<0.05) and CRP (r=-0.587,P<0.05); Omentin-1 was positively related to vaspin (r=0.643,P<0.05). Multiple linear stepwise regression analysis showed that plasma levels of omentin-1 and vaspin might be affected by CRP, TC and LDL-C. Conclusion: ACS patients had decreased plasma levels of omentin-1 and vaspin; in addition, omentin-1 and vaspin might be involved in lipid metabolism.