Clinical observation of poractant alfa injection combined with nasal continuous positive airway pressure in the treatment of premature infants with respiratory distress syndrome / 中国基层医药

ABSTRACT

Objective To observe the clinical effect of poractant alfa injection(curosurf)combined with nasal continuous positive airway pressure(CPAP)in the treatment of neonatal respiratory distress syndrome(NRDS). Methods Fifty patients of infants with NRDS were divided into 25 cases of observation group(curosurf combined with CPAP)and 25 cases of control group(CPAP)according to the methods of the treatment.The differences in treatment efficacy rate and arterial blood gas index were compared.Results The efficacy rate of the observation group (88%)was higher than that of the control group(56%),the difference between the two groups was statistically significant(χ2 =4.861,P <0.05 ).After the treatment,the arterial blood gas index of the observation group were improved obviously compared with that before the treatment,the differences were statistically significant(all P <0.05).After the treatment,the arterial blood gas index of the control group were improved obviously compared with that before the treatment,the differences were statistically significant(all P <0.05).After treatment,the differences in pH value,PaO2 and PaCO2 of the observation group were statistically significant compared with the control group(t =6.00,8.49,4.46,all P <0.05).Conclusion Poractant alfa injection combined with nasal CPAP in the treatment of NRDS is better than using CPAP alone.