Application of stereotactic body radiation therapy in early stage non-small-cell lung cancer / 肿瘤研究与临床

ABSTRACT

Stereotactic body radiation therapy (SBRT) has been increasingly used in the treatment of early-stage non-small-cell lung cancer (NSCLC).Different from conventional radiotherapy,SBRT is characterized by the delivery of high-dose radiation in 1 to 5 fractions with a high degree of precision and steep dose gradients that minimize the dose to normal tissues,and image guidance technology,image fusion technology and respiratory gating system make the therapy more accurate.SBRT delivers higher biological equralent dose (BED) than conventional radiotherapy.The latest small sample data have suggested outcomes for SBRT patients that superior to the success rate of surgery,and the evidence for SBRT over conventional radiotherapy has resulted in a major change in the standard of care for inoperable NSCLC patients.