Study on the Acute Eye Toxicity of PP1 Liposomes / 中国药师
China Pharmacist
;
(12): 1036-1040, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-493284
ABSTRACT
Objective:
To observe the acute toxic side effects of liposome PP 1 topically applied in eyes .Methods:
PP1 liposomes (10, 60, 400 μmol· L-1 ) were used in one eye of SD rats , 4 times daily.The changes of conjunctiva , cornea and iris were observed under the slit-lamp biomicroscope , for three consecutive days , and evaluated by the stimulus score sheet of anterior segment .One week after the treatment , the corneas , irises and lenses were isolated , and their changes were observed under the light microscope .The ul-trastructural changes of corneal epithelial cells and endothelial cells were observed under the electron microscope .Results:
There was a little of conjunctival secretion in one rat in the first day after the treatment with 400 μmol· L-1 PP1 liposomes, and the other rats were not irritant reaction .The corneal fluorescein staining of all rats were negative .The structures of cornea , iris, lens tissue were normal after given different concentrations of PP1 liposomes.Conclusion:
PP1 liposomes at Low, medium and high concentrations show no a-cute eye toxicity in SD rats .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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