Transmembrane Adaptor Proteins Positively Regulating the Activation of Lymphocytes
Immune Network
;
: 53-57, 2009.
Article
in English
| WPRIM
| ID: wpr-49349
ABSTRACT
Engagement of the immunoreceptors initiates signaling cascades resulting in lymphocyte activation and differentiation to effector cells, which are essential for the elimination of pathogens from the body. For the transduction of these immunoreceptor-mediated signals, several linker proteins termed transmembrane adaptor proteins (TRAPs) were shown to be required. TRAPs serve as platforms for the assembly and membrane targeting of the specific signaling proteins. Among seven TRAPs identified so far, LAT and LIME were shown to act as a positive regulator in TCR-mediated signaling pathways. In this review, we will discuss the functions of LAT and LIME in modulating T cell development, activation and differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxides
/
Lymphocyte Activation
/
Lymphocytes
/
Proteins
/
Calcium Compounds
/
Membranes
Language:
English
Journal:
Immune Network
Year:
2009
Type:
Article
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