Circular RNA and the relation of carcinoma / 中国综合临床

ABSTRACT

Objective Cyclic RNA ( circRNAs) was discovered in 1970s,which is different from other RNA,its structure is special,which is a closed covalent ring structure,and shows high and stable expression in eukaryotic cells?In recent years, the study found that a large number of endogenous circRNAs exists in mammalian cells,and most circRNAs with stable expression,RNA enzyme degradation resistance,usually in the tissue cells with the characteristic of diversity and specificity?CircRNAs most formed by exons,part formed by introns?For the functional study of circRNAs,circRNAs has a similar competitive endogenous RNA ( ceRNA) of the sponge function,but also can regulate transcription and translation?More and more evidence indicates that circRNAs circRNAs may be abnormal expression in many diseases,especially in tumor cells?This could be some new diagnostic and predictive biomarkers of disease?CircRNAs in the field of RNA is becoming a new research hotspot,and can be widely involved in many areas of life.