Analysis of risk factors and distribution characteristics in first-ever acute ischemic stroke with large ar-tery atherosclerotic stenosis / 中国神经精神疾病杂志

ABSTRACT

Objective To investigate the distribution characteristics and risk factors of intracranial atherosclerotic stenosis ischemic stroke. Methods We retrospectively collected 342 consecutive patients with first-ever ischemic stroke. Clinical data was collected including demographics, the presence of risk factors,MRI with MRA and other routine admis?sion laboratory tests. Results Intracranial atherosclerotic stenosis (ICAS) was located most frequently in MCA (47.0%), Extracranial internal carotid artery was the most common affected artery (65.0%) among extracranial atherosclerotic steno? sis (ECAS). MetS (OR=1.586,95%CI1.232~2.268), ApoB/ApoA1 ratio (OR=1.926,95%CI1.051~4.288), were as?sociated with ICAS (vs ECAS), whereas hypertension (OR=3.603,95%CI1.675~12.485), MetS (OR=2.268,95%CI1.274~6.103), HbA1c (OR=2.015,95%CI1.182~5.613) and ApoB/ ApoA I ratio (OR=1.948,95%CI1.157~4.285) were related to ICAS (vs NCAS). Hypertension (OR=2.437,95%CI1.492~3.505,P=0.005), Hcy (OR=2.437,95%CI1.492~3.505,P=0.005) and HbA1c (OR=1.769,95%CI1.034~3.121, P=0.005) were the independent risk factors re?lated to posterior circulation strokes (vs anterior circulation strokes ) in ICAS strokes. Conclusions The occurrence of ICAS may be more frequent than that of ECAS in ischemic stroke. Posterior circulation ICAS strokes seems to be close?ly associated with metabolic derangement.