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Anti-bacterial Effects of Baicalin on One Escherichia coli Strain Carrying NDM-1 Gene / 现代检验医学杂志
Journal of Modern Laboratory Medicine ; (4): 124-126, 2016.
Article in Chinese | WPRIM | ID: wpr-493763
ABSTRACT
Objective To examine the bacteriostasis of baicalin against Escherichiacoli strain carrying NDM-1 gene.Methods Minimal inhibitory concentration(MIC)and minimal bactericidal concentration(MBC)were determined by broth dilution method.Synergy function was designed withcheckerboard method.Anti-infection effect in vivo of baicalin was observed in mice with bacteremia.Results In vitro antibacterial tests showed that the MIC and MBC baicalin were 8 mg/ml.Synergistic inhibitory effect was observed between baicalin and imipenem (FIC=0.125).In vivo inhibition experiments showed that ba-icalin had decreased the mortality of 25% of Escherichiacoli Strain carrying NDM-1 gene infection in mice.Conclusion Ba-icalin has antibacterial effect on NDM-1 E.coli.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Modern Laboratory Medicine Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Modern Laboratory Medicine Year: 2016 Type: Article