Advances in research on molecular mechanisms and target diagnosis of gastric cancer / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6): 461-472, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-494309
ABSTRACT
Multiple cellular factors and molecular signal pathways including PI 3K/AKT pathway;MAPK pathway;growth factors and receptors like HER , VEGF/VEGFR and MET ;inflammation‐related factors like COX‐2 ,NF‐κB ,STAT and interleukins ,are involved in the occurrence and development of gastric cancer ,these factors play a key role in apoptosis inhibition ,proliferation promotion and cell cycle regulation of gastric cancer cells ,as well as invasion ,migration and angiogenesis of stomach malignancy .They are also expressed at a higher level in gastric cancer tissue compared with normal gastric mucosa and characterized as biomarkers ,whose target therapies mostly have been in clinical trials . Based on these theoretical foundations , the research on molecular diagnosis of gastric cancer has made some progress .Instruments for target detection tend to be mature .However , the research of molecular probes is still in pre‐clinical trials ,which remains to be further developed .
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS