Sustained-release carriers of insulin:applications and existing problems / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 4532-4538, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-494637
ABSTRACT
BACKGROUND:
Sustained-release carriers of insulin shaped as microspheres made of different biomaterials have become an issue of concern.OBJECTIVE:
To summarize the carrier materials and methods to prepare sustained-release microspheres of insulin.METHODS:
Wanfang and PubMed databases were retrieved by computer for articles related to sustained-release carriers of insulin published from 1997 to 2015. The search terms were“insulin, control ed-release carrier, biomaterials”in Chinese and English, respectively. RESULTS ANDCONCLUSION:
Natural biodegradable polymer materials are preferred to prepare sustained-release microspheres of insulin, including gelatin, alginate, chitosan and its derivatives. These natural materials have good biocompatibility, degradability, film-forming and microsphere-forming abilities. Synthetic biodegradable polymer materials as carrier materials can promote drug stability and effective utilization, and realize targeted drug delivery. According to different physicochemical properties of materials, sustained-release carriers of insulin that meet different requirements can be prepared using emulsion-chemical crosslinking, spray drying and solvent evaporation methods. This review provides new insight into the development of stable drug carriers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS