Skeletal muscle sarcopenia:molecular mechanisms, prevention and treatment / 中国组织工程研究

ABSTRACT

BACKGROUND:There is an urgent need to explore the loss of skeletal muscle mass during aging (sarcopenia), and its molecular mechanisms of action, and prevention and treatment strategies. OBJECTIVE:To summarize the latest progress in molecular mechanisms of sarcopenia, and to provide a fundamental for promoting functional recovery and regeneration of skeletal muscle. METHODS:A computer-based online search was conducted in PubMed and Wanfang databases from 2005 to 2015 to screen the relevant literatures using Chinese and English key words“sarcopenia, skeletal muscle, mechanism, therapy”, respectively. Consequently, 31 eligible literatures were col ected, summarized, and analyzed. RESULTS AND CONCLUSION:Sarcopenia is closely correlated with oxidative stress caused by mitochondrial respiratory failure, inhibition of activating factors for regulating satel ite cel s, reduction in insulin secretion, decreased sensitivity, protein synthesis, and low protein diet. There are common features and molecular mechanisms in sarcopenia and disuse muscle atrophy. Further exploration of exercise and diet strategies for the treatment of sarcopenia is required.