Formula Optimization of Junduqing Dispersible Tablets / 中国药师
China Pharmacist
;
(12): 1221-1223, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-494898
ABSTRACT
Objective:
To optimize the formula of Junduqing dispersible tablets .Methods:
Using appearance , disintegration time and dispersing uniformity as the indices ,the types of filler, disintegrating agent and adhesive were optimized by single factor tests;the amount of filler and disintegrating agent was optimized by orthogonal experiments with the disintegration time as the index ; using ap-pearance and sticking as the indices , the single factor tests were also used to optimize the lubricant , and the adding method of disinte-grating agent was optimized using disintegration time as the index .Results:
For 500 tablets, the amount of Junduqing extract was 61.25 g, microcrystalline cellulose (52.5 g) and dextrin (17.5 g) were used as the fillers, crospolyvinylpyrrolidone (8.75 g) and croscarmellose sodium (26.25 g) were applied as the disintegrating agents , 70% ethanol was the binder , magnesiumstearate (3 g) and talcum powder (2.25 g) were used as the lubricants , and stevioside (3.5 g) was the flavoring agent .Conclusion:
The formula is reasonable and feasible ,which provides reference for the preparation of Junduqing dispersible tablets .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS