Curative Effect of Phosphocreatine Adjuvant Treatment on Neonatal Hypoxic-Ischemic Myocardial Lesion / 中国药师

ABSTRACT

Objective:To discuss the curative effect of phosphocreatine adjuvant treatment on neonatal hypoxic -ischemic myocardi-al lesion and its influence on serum IL-6 and myocardial enzyme .Methods:Totally 80 cases of newborns with hypoxic-ischemic myo-cardial lesion were divided into the observation group and the control group at random .The two groups were given the routine medical treatment, including maintenance of ventilation , warmth, water-electrolyte and acid-base balance, heart rate, blood pressure, nutrition support and etc, while the newborns in the control group were additionally given 250 mg· kg-1 1,6 diphosphate (FDP), ivgtt bid, for 10 days, while those in the observation group , were additionally given 1.0g phosphocreatine dissolved in 100 ml 0.9% normal saline (NS) on the basis of the treatment of the control group , ivgtt qd, for 10 days.The clinical curative effect and security were observed and the changes of serum IL-6 and myocardial enzyme in the two groups were compared .Results: The levels of LDH, CK, CK-MB and serum IL-6 in the two groups were obviously declined when compared with those before the treatment (P<0.05 or P<0.01), and the declining rate of the observation group was higher than that of the control group (P<0.05).The total clinical efficiency of the ob-servation group was higher than that in the control group after the medical treatment (P<0.05), and no serious untoward effect ap-peared in the two groups during the medical treatment .Conclusion: Phosphocreatine has significant curative effect on neonatal hy-poxic-ischemic myocardial lesion , which can effectively improve myocardial function of newborns and reduce myocardial enzyme and se -rum IL-6 levels.