Expression of STAT3 and IL-6 in epilepsy rat caused by penicillin / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1112-1117, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-495099
ABSTRACT
Objective:
To investigate the expression of IL-6 and STAT3 in the epilepsy rat caused by penicillin .Methods:
The model of epilepsy in rats was made by abdominal injecting penicillin .Then the EEG and behavior was observed in each group and the level of IL-6/STAT3 transcription and cytokine IL-6 secretion in different groups was compared using qRT-PCR and ELISA respectively.The protein expression of STAT3 was detected using Western blot.Results:
500 U/kg and 800 U/kg rats injected penicillin were induced epilepsy and show typical epileptic seizures behavioral and brain waves ,seizures was 100%;the level of IL-6/STAT3 transcription and IL-6 secretion in the model of epilepsy was significantly higher than control .There was no significant difference in the expression of STAT3 protein levels,but a significant increase in p-STAT3.Conclusion:
Expression of STAT3 and IL-6 plays an important role in the Epilepsy Rat caused by penicillin .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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