TIPE family:biological activities and functions / 中国免疫学杂志

ABSTRACT

The TIPE( tumor necrosis factor-alpha-induced protein 8-like) family has been recently described as regulators of tu-morigenesis and inflammation .The family consists of four highly homologous members TNFAIP8 ( tumor necrosis factor-α-induced protein 8), TIPE1 (TNFAIP8L1), TIPE2 (TNFAIP8L2) and TIPE3 (TNFAIP8L3).Although TNFAIP8 family share high degrees of sequence homology , the members have different histological expressions , biological functions and molecular targets .TNFAIP8 shows the functions of inhibiting bacterial infection and promoting tumor migration .As a negative regulator of immunity and inflammation , TIPE2 is also an inhibitor of the oncogenic Ras in some neoplastic diseases .TIPE1 can induce cell apoptosis and inhibit tumor .TIPE3 is the transfer protein of phosphoinositide second messengers and can promote cancer .Emerging studies show TIPE family play important regulatory roles in many diseases;however, specific biological activities and exact molecular mechanisms need to be further elucidated .