Study on Acute Toxicity of Xiaobai Capsules in Mice / 中国药师
China Pharmacist
;
(12): 1411-1412, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-495155
ABSTRACT
Objective:
To study the acute toxicity of Xiaobai capsules in mice after intragastric administration .Methods:
The mice were randomly divided into two groups , the treatment group and the control group .The treatment group was given Xiaobai cap-sules by gavage, 3 times daily.The acute toxicity was recorded, and the median lethal dose (LD50) and the maximum dose were deter-mined.Results:
The maximum daily dose of Xiaobai capsules was 141.6 g· kg-1(equivalent to 211.3 times of the clinical dose).At the dose, the mice showed no toxicity without death in 14 days or changes in organs after the dissection .Conclusion:
Xiaobai capsules have very low acute toxicity in mice after intragastric administration with high security .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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