Diagnostic value of combined detection of serum NGAL,CysC,RBP and MMP-2 in diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To investigate the value of the combined detection of NGAL ,CysC ,RBP and MMP‐2 in the diagnosis of type 2 diabetic nephropathy (T2DN) .Methods A total of 149 cases of type 2 diabetes mellitus(T2DM ) were divided into three groups according to the urine protein detection results:normal proteinuria group (NA group) ,micro proteinuria group (MA group) and clinical nephropathy group (CN group) .Contemporaneous 50 individuals undergoing healthy physical examination were selected as the control group (NC group) .The NGAL ,CysC ,RBP and MMP‐2 levels were analyzed and compared among 4 groups .Results The serum NGAL ,CysC and RBP levels in the NA group ,MA group and CN group were significantly higher than in the NC group (P<0 .05 or P<0 .01) ,while the MMP‐2 level was significantly lower than that in the NC group (P<0 .01) .The positive rate of combined detection of NGAL ,CysC ,RBP and MMP‐2 in the NA group ,MA group and CN group were 66 .0% ,85 .7% and 92% respectively ,which were higher than those of single detection (P<0 .05) .NGAL was positively correlated with CysC and RBP (P= 0 .05) and negatively correlated with MMP‐2 (P<0 .05) .Conclusion The serum levels of NGAL ,CysC ,RBP and MMP‐2 in the DN patients are significantly increased ,while the MMP‐2 level is significantlt decreased .Their combined detection can be used as an early monitoring and evaluation index of DN .