The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis
Korean Circulation Journal
;
: 439-445, 2003.
Article
in Korean
| WPRIM
| ID: wpr-49598
ABSTRACT
BACKGROUND AND OBJECTIVES:
Previously, we reported that Abciximab (ReoPro(r))-coated stent inhibited in-stent neointimal hyperplasia. ReoPro(r) is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model. MATERIALS ANDMETHODS:
The surface of the stent was coated with ReoPro(r) by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro(r)-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group In=6, Group IIn=6) and day 28 (Group In=7, Group IIn=7) after stenting.RESULTS:
Pathologic area stenosis was 19.7+/-5.3% in Group I and 15.9+/-3.3% in Group II at day 14, and 33.6+/-27.7% and 22.6+/-6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8+/-6.5% in Group I and 22.5+/-11.6% in Group II at day 14, and 27.3+/-18.3% in Group I and 28.6+/-10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89+/-1.13% in Group I and 1.36+/-1.27% in Group II at day 14, and 6.61+/-5.61% and 6.26+/-4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28.CONCLUSION:
An inflammatory reaction was not suppressed with the use of ReoPro(r)-coated stenting in a porcine stent restenosis model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Polymers
/
Blood Platelets
/
Glycoproteins
/
Stents
/
Follow-Up Studies
/
Constriction, Pathologic
/
Coronary Vessels
/
Transplants
/
Coronary Restenosis
Type of study:
Observational study
/
Prognostic study
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2003
Type:
Article
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