Expression of Beclin1, p62 and Atg5 in tissue of serous ovarian cancer and its significance / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
;
(6): 329-332, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-496019
ABSTRACT
Objective To investigate the expression of Beclin1,p62 and Atg5 in serous ovarian cancer and its clinical significance.Methods The expression of Beclin1,p62 and Atg5 was detected in 50 serous ovarian cancer tissues by immunohistochemical method,and the relationship between their expression levels and the clinical parameters of serous ovarian cancer patients were analyzed.Results The expression of Beclin1 and Atg5 in serous ovarian cancer tissue was significantly lower than that in normal ovarian tissue,but p62 was significantly higher than that in normal ovarian tissue,and the difference had statistically significance (P<0.05).The expression of Beclin1 and Atg5 were correlated with degree of cell differentiation and clinical stage (P<0.05),while the expression of p62 was associated with clinical stages and lymph node metastasis (P<0.05).Conclusions The abnormal expression of Beclin1,p62,Atg5 in serous ovarian cancer,which can lead to reduced autophagy body formation and autophagy activity,may be involved in the occurrence and development of serous ovarian cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrine Surgery
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS