Progresses in diagnosis and treatment of food protein-induced enteropathy / 国际儿科学杂志

ABSTRACT

Food protein-induced enteropathy (FPE)is a series symptom of chronic diarrhea, malabsorption, hypoproteinemia, malnutrition caused by non-IgE mediated food allergy.The pathogenesis of FPE remains unclear, and may be related to gut mucosal barrier, intestinal bacteria, gastrointestinal immunity, oral tolerance and genetic, etc.Histology performance of FPE is characterized by flat atrophy of the small intestine.Diagnosis of PFE relies on history, mucosal histological changes, and oral food challenges.Food eliminate is the mainstay of FPE management.The paper reviews the pathogenesis, clinical manifestation, diagnosis and treatment of FPE to improve the recognition of clinicians.