New insight of soluble biomarkers of ovarian cancer / 中华检验医学杂志

ABSTRACT

Ovarian cancer has the highest mortality rate among cancers of female reproductive system.Early stage of ovarian cancer shows no signs or asymptomatic and no effective screening approach is available.Soluble biomarkers represent the biomarkers existing and can be detected in the body fluid .The detection of soluble biomarkers possess the advantages of being relatively simple , minimal invasive, and low costs, thus they are very useful in screening , therapeutic response monitoring , and prognosis prediction of cancer.However, biomarkers used for ovarian cancer diagnosis are limited , and the overall sensitivity and specificity of the tests are still below clinical satisfaction currently .Thus, seeking for new ovarian cancer soluble biomarkers is current research focus.This paper discuses the features and diagnostic value of current and potential ovarian cancer biomarkers , the reasonable combination strategy in detection of ovarian cancer biomarkers in clinical practice is also discussed .