Progress in diagnosis and treatment of children with neuropsychiatric systemic lupus erythematosus / 国际儿科学杂志

ABSTRACT

Neuropsychiatric systemic lupus erythematosus(NPSLE)of children is a serious complication of children with systemic lupus erythematosus (SLE),and the incidence is even up to 95 ％.The pathogenic pathogenesis of NPSLE maybe result from participation of many factors including the blood-brain barrier damage,blood clots,neuroendocrine disorders,autoantibody production and inflammatory mediators.Its clinical manifestations are complexity and diversity.Headache,epilepsy,mental disorders are comom in children with NPSLE.There is no unified diagnosis for NPSLE,which must be evaluated by the general methods including immunoserological testing,cerebrospinal fluid testing,neuroimaging and neuropsychological assessments.The management of patients with NPSLE consists of immunosuppressive,biotherapy and symptomatic therapies.Early diagnosis and standard treatment may improve the prognosis of children with NPSLE.