Immuno-regulatory effects on murine macrophages by low dose naltrexone (LDW) / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 970-973, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-496540
ABSTRACT
Objective:
The effect of naltrexone on function of murine peritoneal macrophage in vitro was studied in order to illuminate its immune activity futher.Methods:
Peritoneal macrophages were divided in three groupsRPMI1640 blank control group, LPS positive control group and NTX treated group. Various phenotypic and functional indices were tested by MTS, flow cytometry technology,phagocytosis experiment and ELISA.Results:
Compared with RPMI1640 group,at a LDN exhibits paradoxical properties;the expression of CD64 on surface increased while the expression of CD206 decreased in NTX group;the expression of tumour necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β)were increased.Conclusion:
The results of experiment had proved that LDN could influence macrophage polarzation, regulate the inflamatory mediators production and affect the phagocytosis function of peritoneal macrophage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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