Evaluation of the anxiety behavior in acute PD mice induced by MPTP / 中国医师杂志
Journal of Chinese Physician
; (12): 865-867, 2016.
Article
in Zh
| WPRIM
| ID: wpr-496783
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WPRO
ABSTRACT
Objective To investigate the anxious behavior in acute parkinson's mice that were induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.Methods Twenty mice were randomly divided into the control group (n =10) and model group(n =10);The model group was induced by injecting MPTP dosage,and the control group was induced by the same dose of saline.The anxious behaviors in mice were tested by the elevated plus-maze test and the light/dark box.Results The model group mice spent a longer time than the control group in the dark box (P < 0.05).The open arm entry (OE),open arm time (OT) and OE% of model group was significantly less than that in control group in the elevated plus-maze test (P < 0.01),the OT% was significantly less than control group (P <0.05).Conclusions Anxiety symptoms appeared in the model group of early parkinson disease (PD)mice.
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WPRIM
Language:
Zh
Journal:
Journal of Chinese Physician
Year:
2016
Type:
Article