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A Meta-analysis of carbon ion radiotherapy for stage Ⅰ non-small cell lung cancer / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection ; (12): 594-600, 2016.
Article in Chinese | WPRIM | ID: wpr-496866
ABSTRACT
Objective To assess the efficacy and safety of the carbon ion radiotherapy for stage Ⅰ non-small cell lung cancer (NSCLC).Methods We searched multiple electronic bibliographic databases,including the Cochrane library,PubMed,EMBASE,China Journal Full-text Database,Chinese Biomedical Database,and the Wanfang Database to assemble the available studies of carbon ion radiotherapy for stage Ⅰ non-small cell lung cancer.MetaAnalyst Beta 3.13 and STATA 12.0 software were used to combine the extracted data.Results Ten studies (seven trials) were included.The overall survival rates of 1,3 and 5 years were 95.1%,68.5% and 45.9%,respectively.The local control rates of 1,3 and 5 years were 90.2%,76.7% and 81.2%,respectively.The cause specific survival rate of 1,3 and 5 years were 82.9%,58.5% and 57.3%,respectively.The rate of primary recurrence and total recurrence were 45.8% and 11%,respectively.The rates of total death and death from lung cancer were 52.4% and 28.3%,respectively.There were differences observed between T1 stage and T2 stage in regards to five year overall survival rate,total recurrence,lung cancer death,and grade 1 and grade 2 skin toxicities.Conclusions Available data demonstrate that carbon ion radiotherapy,in general,is a safe and feasible treatment modality for stage Ⅰ NSCLC.Although current results are promising,more evidence is required before carbon ion radiotherapy can become the international standard treatment for lung cancer patients.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Systematic reviews Language: Chinese Journal: Chinese Journal of Radiological Medicine and Protection Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Systematic reviews Language: Chinese Journal: Chinese Journal of Radiological Medicine and Protection Year: 2016 Type: Article