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Effects of different concentrations of remifentanil on monophasic action potential in isolated rabbit hearts / 中华麻醉学杂志
Article in Chinese | WPRIM | ID: wpr-496940
Responsible library: WPRO
ABSTRACT
Objective To evaluate the effects of different concentrations of remifentanil on myocardial monophasic action potential (MAP) in isolated rabbit hearts.Methods Adult rabbits of both sexes,weighing 2.0-2.5 kg,were used in the study.Their hearts were excised,and retrogradely perfused with oxygenated K-H solution saturated with 95%O2-5%CO2 at 37 ℃ in a Langendorff apparatus.Twenty-four isolated hearts were randomly divided into 4 groups (n =6 each) using a random number tablecontrol group (group C) and 3 different concentrations of remifentanil groups (group R1-3).After 15 min of stabilization,K-H solution was continuously perfused for 60 min in group C,and K-H solution containing 12,25 and 50 ng/ml remifentanil was continuously perfused for 60 min in R1,R2 and R3 groups,respectively.At 15 min of stabilization,and 15,30 and 60 min of perfusion with K-H solution,the heart rate,and the maximal velocity and amplitude of the MAP in the three layers of the left ventricular anterior wall were recorded,and the action potential duration at 90% repolarization and transmural dispersion of repolarization (TDR) were calculated.Results Compared with group C,the heart rate was significantly decreased,and the action potential duration at 90% repolarization and TDR were significantly prolonged at 15,30 and 60 min of perfusion in R1-3 groups (P<0.05).Compared with C and R1 groups,the maximal velocity and amplitude of MAP were significantly decreased at 15,30 and 60 min of perfusion in R2 and R3 groups (P<0.05).Conclusion Low-concentration remifentanil induces heart block through increasing TDR,however,high-concentration remifentanil induces heart block through inhibiting myocardial MAP depolarization and increasing TDR in the isolated rabbit hearts.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Anesthesiology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Anesthesiology Year: 2016 Type: Article