Impact of maternal obesity on fetus and neonate / 中国小儿急救医学

ABSTRACT

The prevalence of obesity has become one of the most problems that affect human health in 21th Century.The offspring of obese mothers have a higher rate of perinatal morbidity and an increased risk of long-term health problems.Maternal obesity has been associated with high risk of adverse pregnancy outcomes such as stillbirth,congenital malformation of fetus,and an increased rate of cesarean delivery,especially in emergency cesarean section.The notion that an abnormal maternal metabolic environment,through epigenetic modifications,may lead to permanent changes in key organs that underlie fetal/juvenile programming of adult disease,such as obesity,cardiovascular disease,type Ⅱ diabetes and other metabolic syndrome.Therefore,by the weight control of obese gestational age women or the prevention of excessive weight gain during pregnancy,it will significantly decrease the affection of obese mothers on the fetus,reduce the occurrence of adult obesity,diabetes,cardiovascular disease and metabolic syndrome.