Neoplasms chemosensitization enhancing effects of nitric oxide donor compounds / 国际肿瘤学杂志

ABSTRACT

The chemosensitivity enhancive mechanism on nitric oxide includes three routesadjust the expression level of hypoxia-inducible factor-1 α(HIF-1 α),classical nitric oxide signal pathway and combine with the reaction products of other molecules.Traditional nitric oxide donor compounds include nitroferricya-nide,organic nitrates,s-nitrosothiols,azo onium diol aldoxide,non-steroids anti-inflammatory drugs,whose function of antitumor and chemotherapy sensitization caused extensive attention.