Relationships between androgen receptor expression and clinicopathological features and prognosis of early-onset breast cancer in Xinjiang / 国际肿瘤学杂志

ABSTRACT

Objective To study the relationships between androgen receptor (AR)expression and the clinicopathological features and prognosis of young patients (age≤35 years)with early-onset breast cancer in Xinjiang.Methods One hundred and forty-five young patients (age≤35 years)with invasive breast cancer who underwent surgery in Affiliated Cancer Hospital of of Xinjiang Medical University from January 201 0 to December 201 2 were collected.The expressions of AR in 1 45 patiens with early-onset breast cancer were detec-ted by immunohistochemical method.The relationships between AR expression and the clinicopathological fea-tures and prognosis of patients with early-onset breast cancer were retrospective analysed.Results The posi-tive rate of AR expression of patients with early-onset breast cancer in Xinjiang was 69.0% (1 00 /1 45).Single factor analysis showed that AR expression was related with neurovascular invasion (χ2 =5.309,P =0.021 ) and lymph node metastasis (χ2 =6.073,P =0.01 4),but it was not related with ethnicity (χ2 =0.097,P =0.755),age (χ2 =0.045,P =0.831 ),feeding history (χ2 =0.066,P =0.797),family history of cancer (P =0.556),histological grade (P =0.469),tumor size (χ2 =1 .006,P =0.605)and clinical stage (χ2 =4.381 ,P =0.223).The median follow-up time was 47 months.There was no significant difference between AR expression and disease-free survival of patients with early-onset breast cancer (χ2 =1 .972,P =0.1 60). Conclusion Early-onset breast cancer patients with AR positive are more likely to appear lymph node metasta-sis and neurovascular invasion than the patients with AR negative,which has certain guidance means for the treatment of early-onset breast cancer with lymph node metastasis positive.